A probiotic supplement, Lactobacillus rhamnosus GG, and kefir separately can improve mood and exhibit potential anti-depressant-like activities in mice

Abstract Depression is a common psychiatric disorder that can be continuous or recurrent. It has been previously reported intestine probiotics play an essential role in the bidirectional communication of and brain. This study aims to investigate antidepressant effects kefir, probiotic supplement, Lactobacillus rhamnosus GG their potentials depression-like behaviour treatment two-week four-week treatments. In present study, BALB/c mice were used for this purpose. The saline- fluoxetine-treated groups designed as negative positive control groups, respectively. forced swimming tail suspension tests have performed assess level activity. We observed reduces duration activities, enhances properties. Overall, our results suggest L. GG, investigated supplement antidepressant-like